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Chromosome botany
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ISBN: 1578081831 Year: 2002 Publisher: Enfield, USA Science Publishers

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Bacillus subtilis and its closest relatives : from genes to cells
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ISBN: 1555812058 Year: 2002 Publisher: Washington : ASM Press,

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Telomeres and Telomerase : Methods and Protocols
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ISBN: 089603657X 0585404887 9786610821518 1592591892 1280821515 Year: 2002 Publisher: Totowa, NJ : Humana Press : Imprint: Humana,

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The discovery of telomerase expression in a majority of tumors and the recognition of its potential role in the aging process has dramatically raised its profile as a target for therapeutic intervention. In Telomeres and Telomerase: Methods and Protocols, John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible protocols provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non-PCR-based methods to techniques using real-time PCR. Written by investigators who have used the methods extensively, each protocol includes step-by-step instructions, tips on avoiding pitfalls, and invaluable notes that make all the difference to successful experimental outcomes. Broad-ranging and highly practical, Telomeres and Telomerase: Methods and Protocols provides molecular and cell biologists, cancer researchers, and cellular pathologists with the core array of productive techniques needed today to develop telomerase inhibitors and clinically valuable diagnostic/prognostic telomerase markers.

iGenetics
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ISBN: 0805345531 0321181727 Year: 2002 Publisher: San Francisco (Calif.) : Benjamin/Cummings,

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Sex ratios : concepts and research methods
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ISBN: 9780511542053 9780521818964 9780521665780 0521818966 0521665787 0511055145 9780511055140 0511069936 9780511069932 0511170475 9780511170478 0511061471 9780511061479 0511542054 1280430516 9781280430510 0521818966 0521665787 9786610430512 6610430519 1107135591 9781107135598 1139146203 9781139146203 0511297548 9780511297540 Year: 2002 Publisher: Cambridge : Cambridge University Press,

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Covering sex allocation, sex determination and operational sex ratios, this multi-author volume provides both a conceptual context and an instruction in methods for many aspects of sex ratio research. Theory, statistical analysis and genetics are each explained and discussed in the first three sections. The remaining chapters each focus on research in one of a wide spectrum of animal, plant and microbial taxa, including sex ratio distorting bacteria in invertebrates, malarial parasites, birds, human and other mammals, giving critical appraisals of such research. Sex Ratios: Concepts and Research Methods is primarily intended for graduate and professional behavioural and evolutionary ecologists in this field, but it will also be useful to biologists building evolutionary models, and researchers analysing data involving proportions or comparisons across phylogenetically related species.


Periodical
Cytogenetic and genome research.
ISSN: 1424859X Year: 2002 Publisher: Basel ; New York : S. Karger,


Periodical
Cell & chromosome.
ISSN: 14759268 Year: 2002 Publisher: [London] : BioMed Central,

The century of the gene
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ISBN: 9780674039438 0674039432 0674008251 9780674008250 0674003721 9780674003729 Year: 2002 Publisher: Cambridge, Mass. London Harvard University Press

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In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology’s progress from gene to genome in one hundred years, The Century of the Gene also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene—word and object—as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life.

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